Synthesis and characterization of novel Mannich's bases incorporated with Ibuprofen an Biginelli Derivatives

In this work, a series of novel Mannich's bases incorporated with Ibuprofen core and Biginelli derivatives have been reported. The synthesis process was dependent on linking hydrazone Isatin to via methylene group formaldehyde. new compounds characterized using FT-IR spectroscopy, 1H-NMR spectroscopy the physical properties.